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Lucigen provides a wide range of enzymes to for molecular biology and Next Gen Sequencing applications.

  • Enzymes selected to meet your DNA and RNA synthesis needs

Also see enzymes for PCR & Amplification including Bst DNA Polymerase.

Modifying Enzymes

NxGen® T4 DNA Ligase
Reliably join double-stranded nucleic acid chains.
ATP Solution
Stable ATP solution for molecular biology applications.
Ampligase® Thermostable DNA Ligase
A thermostable DNA ligase for high temperature ligation-based applications.
CircLigase™ ssDNA Ligase
A ssDNA ligase well-suited to high temperature ligation-based applications.
CircLigase™ II ssDNA Ligase
A non-catalytic, thermostable ssDNA ligase.
T4 RNA Ligase 2, Deletion Mutant
An improved T4 RNA Ligase for addition of single-stranded adenlylated DNA or RNA oligos to RNA targets.
T4 Polynucleotide Kinase, Cloned
Phosphorylate non-phosphorylated DNA and RNA molecules for use in wide array of downstream applications.
RNA 5´ Polyphosphatase
Dephosphorylate tri- and di-phosphorylated RNA molecules while avoiding 5'-capped and mono-phosphorylated RNAs

DNA Nucleases

RNase-Free DNase I
DNase I with no contaminating RNase activity
Baseline-ZERO™ DNase
Digest large or small DNA molecules better than standard Dnase I
Plasmid-Safe™ ATP-Dependent DNase
Digest unwanted contaminating linear dsDNA without harming circular dsDNA such as plasmids and fosmids.
Exonuclease VII
ssDNA exonuclease with both 5´ to 3´ and 3´ to 5´ exonuclease activities.
Exonuclease III, E. coli
3' exonuclease that is active on nicks, blunt ends and 3'-recessed ends in dsDNA.
Rec J Exonuclease
5' to 3' digestion of single-stranded DNA with this magnesium-dependent exonuclease.
Exonuclease I, E. coli
Digest single-stranded DNA from the 3' to 5' end, but not double-stranded or dsDNA with short 3' overhangs.

RNA Nucleases

Hybridase™ Thermostable RNase H
A thermostable, RNase H for the degradation of RNA in RNA:DNA hybrids.
RNase A
Efficiently degrade unwanted RNA in DNA preparations and other molecular biology samples/reactions.
RNase I, E. coli
Completely digest single-stranded RNA with this heat labile, non-sequence specific RNase
RNase R
A 3´ to 5´ exoribonuclease that digests all linear RNAs except lariat or circular RNA structures making it well-suited to RNA splicing and other research applications.
Terminator™ 5´-Phosphate-Dependent Exonuclease
A 5´ to 3´ riboexonuclease that digests RNA with 5´-monophosphate ends but not RNAs with 5´-triphosphate, 5´-cap or 5´-hydroxyl groups.

DNA and RNA Nucleases

OmniCleave™ Endonuclease
Digests all forms of unwanted DNA and RNA in multiple samples types.


NxGen® phi29 DNA Polymerase
Excellent strand displacement, fidelity and speed.
NxGen® T7 RNA Polymerase
Reliable transcription.
T7 R&DNA™ Polymerase
A mutatated T7 RNA polymerase that incorporates dNTPs as well as normal NTPs into in vitro transcribed RNA
Exo-Minus Klenow DNA Polymerase (D355A, E357A)
A Klenow DNA polymerase lacking all 5' to 3' and 3' to 5' exonuclease activity.
Poly(A) Polymerase Tailing Kit
Add poly(A) tails to the 3' ends of any RNA molecules with this robust kit.

Reverse Transcriptase Enzymes

EpiScript™ RNase H- Reverse Transcriptase
Increase specificity with an RT stable to 55°C.
MMLV High Performance Reverse Transcriptase
Produce more full-length, first strand cDNA
NxGen® M-MuLV Reverse Transcriptase
Outstanding cDNA synthesis.
RapiDxFire™ Thermostable Reverse Transcriptase
Generate short cDNAs (<1 kb) quickly at temperatures > 55°C.

RNase Inhibitors

NxGen® RNase Inhibitor
Eliminate RNase activity.
RiboGuard™ RNase Inhibitor
Inhibit RNase activity

Have Questions?

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